The team from University of California San Diego say their electronic biosensor innovation could lead to a range of life saving smart underwear.
Professor Joseph Wang says the system looks at the biomarkers in human sweat and tears to make autonomous diagnoses.
In the future it's though the clever pants could even administer drugs -- and maybe say when they need to be changes.
Speaking of the underwear Wang said: "…putting the electrodes on the underwear, we didn’t plan to make it sexy. Our approach is scientific.
"The waistband of the underwear gives you the best contact with the skin where you expect to get a good sampling of the sweat."